Characters played by Tobey Maguire
Peter Parker
Spider-Man
Characters played by Alfred Molina
Dr. Otto Octavius
Doc Ock
Characters played by Kirsten Dunst
Mary Jane Watson
Characters played by J.K. Simmons
J. Jonah Jameson
Characters played by Mindy Sterling
Aunt May
Additional Voices
Characters played by Jim Meskimen
Narrator
Additional Voices
Characters played by Josh Keaton
Harry Osborne
Additional Voices
Characters played by James Arnold Taylor
Mysterio
Additional Voices
Characters played by Dwight Schultz
Vulture
Additional Voices
Characters played by John DiMaggio
Rhino
Additional Voices
Characters played by Michael Beattie
Shocker
Additional Voices
Characters played by Keith Szarabajka
Mr. Aziz
Additional Voices
Characters played by Herschel Sparber
Additional Voices
Characters played by Peter Lurie
Additional Voices
Characters played by Rocky Carroll
Additional Voices
Characters played by Bethany Rhoades
Additional Voices