Characters played by Dominic Armato
Guybrush Threepwood
Characters played by Earl Boen
The Ghost Pirate LeChuck Sheriff Fester Shinetop
Characters played by Alexandra Boyd
Governor Elaine Marley
Characters played by Leilani Jones
The Voodoo Lady Carla the Swordmaster (as Leilani Jones Wilmore)
Characters played by Cam Clarke
Meathook (and His Tattoo)
Characters played by S. Scott Bullock
Otis the Prisoner Red Skull the Cannibal
Characters played by Patrick Pinney
Stan the Salesman
Characters played by Roger Jackson
Bridge Troll Freddy - Man of Low Moral Fiber Jojo the Monkey Meathook's Parrot Piranha Poodle Pirate Leader II Rat Spiffy the SCUMM Bar Dog (as Roger L. Jackson)
Characters played by Rob Paulsen
Alfredo Fettuccini Bob the Ghost Pirate Lookout Ghost Priest
Characters played by Jess Harnell
Bill Fettuccini Estevan - the SCUMM Bar Pirate Pirate Leader I Store Keeper Sword-Head Ghost
Characters played by Jarion Monroe
Mancomb Seepgood Captain Smirk Navigator Head SCUMM Bar Cook
Characters played by Wally Wingert
Biff the Ghost Franklin, Man of Low Moral Fiber Herman Toothrot Swordfight Opponent I
Characters played by Denny Delk
Narrator Pirate Leader III Shifty Melee Citizen
Characters played by David W. Collins
Cobb - the SCUMM Bar Pirate Lemonhead the Cannibal Mystery Pirate I Swordfight Opponent II
Characters played by Patrick Hallahan
Bouncer Sharptooth the Cannibal Phineas, Man of Low Moral Fiber Mystery Pirate II