Characters played by Charles Fleischer
Roger Rabbit
Characters played by Kathleen Turner
Jessica Rabbit
Characters played by April Winchell
Mom
Young Baby Herman
Characters played by Lou Hirsch
Adult Baby Herman
Characters played by Corey Burton
Droopy Dog (segments "Roller Coaster Rabbit" and "Trail Mix-Up)
Characters played by Frank Welker
Various
Characters played by Richard Williams
Droopy Dog (segment "Tummy Trouble")