Characters played by Hayden Panettiere
Amanda Knox
Characters played by Marcia Gay Harden
Edda Mellas
Characters played by Vincent Riotta
Guiliano Mignini
Characters played by Paolo Romio
Raffaele Sollecito
Characters played by Amanda Fernando Stevens
Meredith Kercher
Characters played by Heather Cave
Deanna Knox
Characters played by Djibril Kébé
Rudy Guede
Characters played by Timothy Martin
Patrick Lumbana
Characters played by Clive Walton
Curt Knox
Characters played by Shobu Kapoor
Arlene Kercher (as Shoboo Kapoor)
Characters played by Mimosa Campironi
Filomena Romanelli
Characters played by Simonetta Solder
Detective Navarra
Characters played by Fausto Maria Sciarappa
Detective Alicastro
Characters played by Valentina Carnelutti
Dr. Patrizia Stefanoni
Characters played by Francesco De Vito
Ispettore Battistelli